Assessment of mediastinal mass

Last reviewed: 10 Aug 2025
Last updated: 06 Aug 2020

Summary

Differentials

Common

  • Thoracic aortic aneurysm
  • Non-Hodgkin's lymphoma
  • Metastatic cancer
  • Thymoma
  • Lung cancer
Full details

Uncommon

  • Aortic dissection
  • Hodgkin's lymphoma
  • Mediastinal germ cell tumour: seminoma
  • Mediastinal germ cell tumour: non-seminoma
  • Thymic carcinoma
  • Primary tracheal tumours
  • Neurogenic tumour
  • Thyroid neoplasm
  • Substernal goitre
  • Acute lymphocytic leukaemia
  • Chronic lymphocytic leukaemia
  • Pericardial cyst
  • Bronchogenic cyst
  • Oesophageal cyst (includes oesophageal duplication cyst)
  • Mediastinal germ cell tumour: mature teratoma
Full details

Contributors

Authors

Ashok Muniappan, MD

Assistant Professor of Surgery

Division of Thoracic Surgery

Massachusetts General Hospital

Harvard Medical School

Boston

MA

Disclosures

AM declares that he has no competing interests.

Acknowledgements

Dr Ashok Muniappan would like to gratefully acknowledge Dr John Kucharczuk, Dr Mario Gasparri, and Dr Nicholas Choong, the previous contributors to this topic. JK, MG, and NC declare that they have no competing interests.

Peer reviewers

Marc Baker, MD, PhD

Cardiology Fellow

Department of Internal Medicine

Cardiology Division

University of Rochester

Rochester

NY

Disclosures

MB declares that he has no competing interests.

Abe DeAnda Jr., MD, FACS, FAHA

University Associate Professor

Cardiothoracic Surgery

Albert Einstein College of Medicine

Director Aortic Surgery

Montefiore Medical Center

Bronx

NY

Disclosures

AD declares that he has no competing interests.

Shahab A. Akhter, MD

Assistant Professor of Surgery

Section of Cardiac and Thoracic Surgery

The University of Chicago

Chicago

IL

Disclosures

SAA declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest. 2005;128:2893-2909.Full text  Abstract

Silvestri GA, Gonzalez AV, Jantz MA, et al. Methods for staging non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e211S-e250S.Full text  Abstract

Annema JT, van Meerbeeck JP, Rintoul RC, et al. Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA. 2010;304:2245-2252.Full text  Abstract

Marom EM, Milito MA, Moran CA, et al. Computed tomography findings predicting invasiveness of thymoma. J Thorac Oncol. 2011;6:1274-1281. Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Assessment of mediastinal mass images
  • Guidelines

    • Managing incidental findings on thoracic CT: mediastinal and cardiovascular findings
    More Guidelines
  • Patient information

    Atrial fibrillation: what is it?

    High blood pressure: what is it?

    More Patient information
  • padlock-lockedLog in or subscribe to access all of BMJ Best Practice

Use of this content is subject to our disclaimer